PhD position in Infection Immunology (m/f/d)

Sounds interesting?
Who we are:

The laboratory „Balancing innate immunity“ (Prof. Dr. med. Roland Lang) at the Institute of Clinical Microbiology, Immunology and Hygiene of the University Hospital Erlangen offers a PhD position to investigate mechanisms of helminth-induced inhibition of Th1/Th17 immunity.

Research in the Lang lab investigates how the immune system generates resistance to infection while avoiding excessive inflammation. This includes a need for efficient sensing of microbes by macrophages, generating inflammatory cytokines that direct adaptive immune responses, and regulatory mechanisms to achieve resolution of inflammation. A focus of our interest has been the role of myeloid C-type lectin receptors like Mincle in the detection of mycobacteria (the bacteria causing tuberculosis). Mincle signaling through Syk-Card9 in myeloid cells induces strong Th17 immune responses. Since we found that the Th2 cytokines IL-4/IL-13 inhibit expression of Mincle and related C-type lectin receptors, we have started to analyze the contribution of this regulation to inhibition of vaccine-induced Th1/Th17 immune response during helminth infection (Schick et al. 2023 eLife).

Lab homepage: https://www.mikrobiologie.uk-erlangen.de/forschung/forschergruppen-arbeitsgruppen/ag-prof-r-lang/