Computational Postdoc - Effects of in-utero exposure to antiseizure medications (f/m/d)

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Epilepsies affect 50 million people worldwide, impacting equally men and women. In the US, more than half a million women of childbearing age are diagnosed with epilepsy and continue to be treated during their pregnancy and breastfeeding. The development of the nervous system is a critical phase during which environmental insults via the mother can have short- and long-term consequences. This is the reason why psychoactive drugs can have deleterious consequences on brain development of offspring when they are consumed during pregnancy and lactation. Many reports demonstrate that anti-seizure drugs (ASDs) are teratogenic and could, e.g., cause brain malformations or psychiatric disorders in a drug- and dose-dependent manner, which led to changes in prescription guidelines, particularly for valproic acid (VPA). However, there is not enough data yet regarding the “new” ASDs to extend these recommendations.
Beyond the first generation, exposure to ASDs may result in epigenetic changes to germ cells (sperm o